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CLASS: HIV protease inhibitor PI ; STANDARD DOSE: Two 200 50 mg tablets twice a day or four 200 50 mg tablets once daily for first time therapy no oncedaily dose if taken with Sustiva or Viramune ; . Three tablets twice a day may be considered for treatment experienced or those taking it with Sustiva or Viramune. Soft-gelatin capsules 133.3 mg lopinavir and 33.3 mg ritonavir each ; were phased out in early 2006. Take with or without food, preferably with food to lessen side effects; liquid formula available. Take missed dose as soon as possible, but do not double up on your next dose. AWP: $764.41 month MANUFACTURER CONTACT: Abbott Laboratories, kaletra , 1 800 ; 2226885 AIDSINFO: 1 800 ; HIV0440 4480440 ; , aidsinfo.nih.gov POTENTIAL SIDE EFFECTS AND TOXICITY: Diarrhea is the most common. Rash, nausea, vomiting, stomach pain, headache, muscle weakness, increased cholesterol and triglycerides fats in the blood ; , and AST ALT liver function tests, a sign of liver damage; this may be more common in people with hepatitis B or C ; seen with other protease inhibitors, there can be increased levels of cholesterol and triglycerides except possibly unboosted Reyataz ; which may be associated with an increased risk of heart disease. Other possible side effects are lipodystrophy body fat changes, including thinning of the face, arms and legs, with or without fat accumulation in the stomach, breasts and sometimes the upper back ; , onset of new cases or worsening of diabetes see your doctor promptly ; and increased bleeding in hemophiliacs. POTENTIAL DRUG INTERACTIONS: Interacts with many--tell your provider all the drugs you are taking. Do not take with Tambocor, Rythmol, Cordarone, Versed, Halcion, Uroxatral, Rifadin, Orap, ergot derivatives such as Cafergot, Wigraine and Methergine, D.H.E. 45 ; , garlic supplements, or the herb St. John's wort. Do not use Zocor or Mevacor; lipid-lowering alternatives are Lipitor, Lescol, and Pravachol, but they should be used with caution due to potential for liver toxicity. Oral solution contains alcohol, so do not use with Antabuse or Flagyl. Avoid certain calcium channel blockers. Dosage of methadone may need to be increased when taken with Kaletra. Increase Kaletra dose to three tablets twicea-day with food recommended when using with Sustiva or Viramune in people who previously took HIV drugs, especially protease inhibitors. Not recommended to be taken with Lexiva. Kaletra may lower levels of Retrovir and Ziagen. Videx should be given an hour before or two hours after Kaletra, if Kaletra is taken with food. Mycobutin rifabutin ; dosage should be reduced to 150 mg every other day or 150 mg three times per week ; when used with Kaletra. Phenobarbital, phenytoin or carbamazepine may lower blood levels of Kaletra. Reduces effectiveness of birth control pills; use alternative contraceptive. Mepron levels may be reduced with Kaletra. Avoid Sporanox doses greater than 200 mg per day with Kaletra. People with kidney impairment may require lower Biaaxin doses with Kaletra. Transplant medicines require close monitoring with Kaletra. Kaletra may alter coumadin levels. Steroids, especially Decadron, may decrease levels of Kaletra. Protease inhibitors increase blood levels of Viagra, Cialis and Levitra. Use with caution. Initially the Viagra dose should be 12.5 mg 1 2 of 25 mg tablet ; and increased as needed and tolerated. It's recommended that people on PIs do not exceed 25 mg of Viagra in a 48-hour period because of potential for serious reaction such as low blood pressure, visual changes, and prolonged erection leading to permanent tissue damage. Use Cialis at reduced doses of 10 mg every 72 hours and Levitra at reduced doses of no more than 2.5 mg every 72 hours, with increased monitoring for adverse events. TIPS: Kaletra twice daily was the first protease inhibitor recommended by U.S. treatment guidelines for first-time therapy. The new tablet formulation of Kaletra with the same dosage but less pills and hopefully fewer side effects. The newer formulation doesn't require refrigeration especially important for resource-poor countries ; and has fewer food restrictions. Three capsules equal two tablets, except for patients also taking Sustiva or Viramune. Great viral load results out to 7 years in people on their fi rst HIV regimen. Good results also seen in heavily treatment-experienced adults, when compared to Reyataz, even those with protease inhibitor resistance. Use Kaletra with caution in people with mild to moderate liver impairment. The taste may be unappealing due to Norvir. Four tablets once daily can increase side effects. Solution 40% alcohol with peppermint taste ; should be stored in the refrigerator, but is stable for up to 60 days at room temperature 77 F ; . However, avoid extreme heat and bright light. Effective in some campaigns as interpersonal communication. Sometimes peer counselling or group workshops are more effective because they provide an opportunity for clarification or feedback. More often than not, health communication is most effective when many different communication channels are used simultaneously. A combination of community, interpersonal and mass media channels takes advantage of the strengths of each and provides maximum exposure to your message. 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