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415 received C.E.R.A. Q4W and 417 continued with epoetin QW-TIW. Dose was adjusted to maintain Hb within 1.0 g dL of baseline and within 10.0-13.5 g dL. A post-hoc analysis evaluated the impact of age and gender on Hb levels in patients receiving C.E.R.A. Q4W. Results: Mean Hb levels at baseline were similar for patients 65 and 65 years 11.8 vs 11.7 g dL ; and males and females 11.7 vs 11.8 g dL ; . C.E.R.A. Q4W maintained stable Hb levels between baseline and the evaluation period, with minimal changes in mean Hb in patients 65 and 65 years -0.18 vs -0.34 g dL ; . Mean Hb changes observed in male and female patients treated with C.E.R.A. Q4W were also similar -0.21 vs -0.30 g dL ; . Iron parameters were well maintained throughout the study and were comparable across treatment groups. C.E.R.A. was well tolerated, with a safety profile characteristic of the patient population. Conclusion: These Phase III data indicate that C.E.R.A. once monthly effectively maintains stable Hb levels in patients on dialysis who convert directly from epoetin QW-TIW. Similar results were observed with C.E.R.A. once monthly in both younger patients and those aged 65 years and in male and female patients. These findings support the use of C.E.R.A. once monthly in dialysis patients of all ages, including the growing population of those aged 65, providing an opportunity for improved care while potentially reducing the workload of healthcare professionals. References: 1. USRDS 2006 Annual Report, for example, medicines.

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CONSUMER HEALTHCARE Consumer Healthcare sales grew 2% with growth in International + 7% ; and North American + 5% ; markets offsetting lower sales in Europe -2% ; . Operating profit for the business grew 23% benefiting from a favourable sales mix growth from higher margin products ; , cost containment and lower advertising spending. Over-the-counter medicine sales were 343 million + 5% ; . Sales growth was led by smoking control products which grew 17%, reflecting strong momentum behind the Commit lozenge in the USA and Europe. Oral care sales were down 1% to 219 million. International sales were up 11% with strong performances by the Aquafresh, Sensodyne, Polident and Poligrip brands. Sales in Europe were down 6% versus a year ago, which benefited from the launch of new whitening products. Nutritional healthcare products sales grew 1% to 135 million. FINANCIAL REVIEW These results have been prepared under International Financial Reporting Standards see Accounting Presentation and Policies on page 16 ; . Operating profit and earnings per share Operating profit for Q1 2005 was 1, 747 million, an 18% increase in CER terms 17% in sterling terms ; compared with Q1 2004. EPS of 21.1 pence increased 19% in CER terms 17% in sterling terms ; compared with Q1 2004 EPS. The adverse currency impact of 2% reflected a weaker US dollar, partially offset by a stronger Euro. EPS growth benefited by 4% due to higher asset sale profits primarily the sale of certain Levirra Europe and International rights ; , partly offset by higher provisions for legal matters and higher charges relating to programmes to deliver future cost savings. Excluding these items, EPS grew 15%. This was above the rate of sales growth primarily due to lower SG&A costs arising from cost savings and the phasing of advertising and promotional expenses. Currencies The first quarter 2005 results are based on average exchange rates, principally 1 $1.91, 1 Euro 1.44 and 1 Yen 199. The period-end exchange rates were 1 $1.89, 1 Euro 1.45 and 1 Yen 202. Dividend On 28th April 2005 the Board declared a first interim dividend of 10 pence per share. This compares with a dividend of 10 pence per share for Q1 2004. The equivalent dividend receivable by ADR holders is 38.0090 cents per ADS based on an exchange rate of 1 $1.90047. The dividend will have an ex-dividend date of 12th May 2005 and will be paid on 1st July 2005 to shareholders and ADR holders of record on 14th May 2005. Under IFRS the liability for a dividend is only recognised in the period when it is declared and so the Q1 2005 financial statements do not reflect this first interim dividend. Earnings guidance On an IFRS basis, 2005 EPS percentage CER growth is expected to be in the low double-digit range. Share buy-back programme In October 2002 GSK commenced a new 4 billion share buy-back programme. At 31st December 2004 2, 199 million had been accounted for from this programme. A further 206 million was spent in Q1 2005. The exact amount and timing of future purchases, and the extent to which repurchased shares will be held as Treasury shares rather than being cancelled, will be determined by the company and is dependent on market conditions and other factors and soma and levitra.

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This metabolite had less affinity approximately 1 2, 000 ; than the parent drug for the glucocorticoid receptor of human lung cytosol in vitro and negligible pharmacological activity in animal studies.
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