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General Issues Sub-group meeting on Harmonisation of SPCs There was a meeting of the Sub-Group on harmonisation of SPCs, mainly to consider the initial proposals from Member States for products for which a harmonised SPC should be drawn up. The Sub-group considered also the number of products that may be referred to the CHMP for arbitration and future cooperation with Interested Parties. The Sub-Group agreed to meet with Interested Parties as needed. The CMD h ; Sub-Group on harmonisation of SPCs will continue its work with a view to laying down a list of medicinal products for which a harmonised SPC should be drawn up, taking into account the proposals from all Member States, in accordance with Article 30 2 ; of Directive 2001 83 EC, as amended. List of Guidance documents in the Mutual Recognition Procedure under revision & Publication and consultation of MRFG CMD h ; Guidance documents on the implementation of the new legislation The CMD h ; has updated the lists of Guidance documents in the MRP under revision & Publication and consultation of Guidance documents on the implementation of the new legislation, to reflect the current status of the documents under revision preparation by the CMD h ; , in accordance with the new legislation. Urgent Safety Restriction Member States' Standard Operating Procedure The CMD h ; has considered the comments received from Interested Parties on the Urgent Safety Restriction Member States' Standard Operating Procedure. The updated SOP, agreed by the CMD h ; and PhVWP, will be published on the website. Best Practice Guide EU Work Sharing Procedure in the Assessment of Paediatric Data The CMD h ; has updated the Best Practice Guide for the EU Work sharing procedure in the assessment of paediatric data, mainly with regard to the content of the application and to give further clarification on the role of the Rapporteur and Co-Rapporteur in the procedure. The updated BPG will be published on the website. Informal CMD h ; meeting An informal CMD h ; meeting will be held in Vienna on 18-19 May 2006. The meeting will be mainly focused on Member States experience with the new legislation, including the new decentralised procedure, referrals to CMD h ; and the work within the CMD h ; . The transparency requirements of the new legislation, consultation with target patient groups, usage patents and harmonisation of package leaflets will also be on the Agenda for the meeting.
International Peat Society Vapaudenkatu 12 FIN-40100 Jyvskyl, Finland Phone: + 358 14 3385 Fax: + 358 14 3385 E-mail: ips peatsociety Web: peatsociety Increased co-operation around growing media research and climate change . 4 IPS for all peat people . 5 IPS and ISHS share a common interest: Growing Media - Getting ready for the International Symposium on Growing Media in Angers . 8 Cooperation between IPS and ISHS in organizing events established . 9 Senior Researcher Olli Reinikainen - "The role and characteristics of peat in horticulture are unique" .11 Sphagnum farming - an international workshop in Germany .15 Sphagnum cultivation - looking into the future .16 EPAGMA - A new organisation for a new Europe .21 Peat excavation - Nature conservation - Eco-label: Breaking of taboos and visions .23 Finnish-Canadian Collaboration on Cloudberry Cultivation .28 Invitation to an International Peatland Restoration Workshop in Canada, 3 - 7 October 2005 .31 2nd Regional Workshop on the ASEAN Peatland Management Initiative .34 Admiring North-Karelian peatlands in spring.36 In Memoriam: Wim Tonnis 1933 2005 ; .38 Wim Tonnis Peat Award .39 New contact details for IPS.39 Peat News .39 New IPS Members.39 The Executive Board on the Baltic Sea .40 Decisions of Executive Board Meeting No. 28 in a Nutshell .40 Impact of peatlands and peat on climate .43 The Executive Board visits Sderenergi .44 The IPS Convention in Warsaw .46 Decisions of the Annual Assembly 2005 .46 Decisions of Executive Board Meeting No. 29 in a Nutshell .47 Future IPS Conferences and Symposia.50 Events of related organisations .50 Information for Advertisers .50 and provera.
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1. Garland, C. F., and Garland, F. C. Do sunlight and vitamin D reduce the likelihood of colon cancer? Int. J. Epidemiol., 9: 227231, 1980. Garland, C. F., Garland, F. C., and Gorham, E. D. Can colon cancer incidence and death rates be reduced with calcium and vitamin D? Am. J. Clin. Nutr., 54: 193S201S, 1991. Emerson, J. C., and Weiss, N. S. Colorectal cancer and solar radiation. Cancer Causes Control, 3: 9599, 1992. Holick, M. F., MacLaughlin, J. A., Clark, M. B., Holick, S. A., and Potts, J. T. Photosynthesis of previtamin D in human skin and the physiologic consequences. Science Wash DC ; , 212: 203205, 1980. Garland, C., Shekelle, R. B., Barrett-Connor, E., Criqui, M. H., Rossof, A. H., and Paul, O. Dietary vitamin D and calcium and risk of colorectal cancer: a 19-year prospective study in men. Lancet, i: 307309, 1985. 6. Tangrea, J., Helzlsouer, K., Pietinen, P., Taylor, P., Hollis, B., Virtamo, J., and Albanes, D. Serum levels of vitamin D metabolites and the subsequent risk of colon and rectal cancer in Finnish men. Cancer Causes Control, 8: 615 625, Platz, E. A., Hankinson, S. E., Hollis, B. W., Colditz G. A., Hunter, D. J., Speizer, F. E., and Giovannucci, E. Plasma 1, 25-dihydroxy- and 25-hydroxyvitamin D and adenomatous polyps of the distal colorectum. Cancer Epidemiol. Biomark. Prev., 9: 1059 1065, Holick, M. F. Chapter 18: Vitamin D. In: M. E. Shils, J. A. Olson, M. Shike, and A. C. Ross. Modern Nutrition in Health and Disease, pp. 329 346. Baltimore, MD: Lippincott Williams and Wilkins, 1999. 9. Reichel H., Koeffler, H. P., and Norman, A. W. The role of the vitamin D endocrine system in health and disease. N. Engl. J. Med., 320: 981991, 1989. Adams, J. S., Sharma, O. P., Gacad, M. A., and Singer, F. R. Metabolism of 25-hydroxyvitamin D3 by cultured alveolar macrophages in sarcoidosis. J. Clin. Investig., 72: 1856 1860, Bikle, D. D., Nemanic, M. F., Gee, E., and Elias, P. 1, 25 OH ; 2D3 production by human keratinocytes. Kinetics and regulation. J. Clin. Investig., 78: 557566, 1986. Peehl, D. M., Skowronski, R. J., Leung, G. K., Wong, S. T., Stamey, T. A., and Feldman, D. Antiproliferative effects of 1, 25-dihydroxyvitamin D3 on primary cultures of human prostatic cells. Cancer Res., 54: 805 810, Miller, G. J., Stapleton, G. E., Ferrara, J. A., Lucia, M. S., Pfister, S., Hedlund, T. E., and Upadhya, P. The human prostatic carcinoma cell line LncaP expresses biologically active, specific receptors for 1 , 25-dihydroxyvitamin D3. Cancer Res., 52: 515520, 1992. Holt, P. R., Arber, N., O'Connor, J., Halmos, B., McGlynn, C., Moss, S. F., Pou, R., Yang, K., Fan, K., Newmark, H., and Lipkin, M. Serum 25-hydroxyvitamin D3 inhibits proliferation of colonic epithelial cells in subjects at high risk for colon neoplasia. Gastroenterology, 118: A276, 2000. 15. Holiss, B. W. Assay of circulating 1, 25-dihydroxyvitamin D involving a novel single cartridge extraction and purification procedure. Clin. Chem., 32: 2060 2063, Hollis, B. W., Kamerud, J. Q., Kurkowski, A., Beaulieu, J., and Napoli, J. L. Quantification of circulating 1, 25-dihydroxyvitamin D by radioimmunoassay with 125I-labeled tracer. Clin. Chem., 42: 586 592, Lipkin, M., Enker, W. E., and Winawer, S. J. Tritiated-thymidine labeling of rectal epithelial cells in "non-prep" biopsies of individuals at increased risk for colonic neoplasia. Cancer Lett., 87: 153161, 1987. Yang, K., Fan, K., Newmark, H., Leung, D., Lipkin, M., Steele, V. E., and Kelloff, G. J. Cytokeratin, lectin, and acidic mucin modulation in differentiating colonic epithelial cells of mice after feeding Western-style diets. Cancer Res., 56: 4644 4648, Morrison, N. A., Qi, J. C., Tokita, A., Kelly, P. J., Crofts, L., Nguyen, T. V., Sambrook, P. N., and Eisman, J. A. Prediction of bone mineral density from vitamin D receptor allelles. Nature Lond. ; , 367: 284 287, Christakos, S., Gabrielides, C., and Rhoten, W. B. Vitamin D-dependent calcium binding proteins: chemistry, distribution, functional considerations and molecular biology. Endocrine Rev., 10: 326, 1989. Ghijsen, W. E. J. M., and van Os, C. H. 1 , 25-dihydroxyvitamin D3 regulates ATP-dependent calcium transport in basolateral plasma membranes of rat enterocytes. Biochim. Biophys. Acta, 689: 170 172, Wasserman, R. H., Brindak, M. E., Meyer, S. A., and Fullmer, C. S. Evidence for multiple effects of vitamin D3 on calcium absorption: response of rachitic chicks, with or without partial vitamin D3 repletion, to 1, 25-dihydroxyvitamin D3. Proc. Natl. Acad. Sci. USA, 79: 7939 7943, for example, pletal mg.
The next time someone offers you a fruit or a veggie--eat up! It turns out that fruits and vegetables can help prevent stroke. Researchers looked closely at eight studies involving more than 257, 000 people in Europe, the United States and Japan. Their findings, published recently in the medical journal and ramipril.
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Transmission HBV and HIV share similar routes of transmission. HBV transmission occurs when blood or body fluids from an infected person enters the body of another person. HBV can be spread through unprotected sex with an infected person, sharing needles or "works" when "shooting" drugs, through needle sticks, and from an infected mother to her baby during birth. Vaccine The good news is that hepatitis B is preventable. Hepatitis B vaccines are available for all age groups to prevent the spread of the hepatitis B virus. The vaccine enables the body to produce antibodies against Hepatitis B infection The FDA has approved two vaccines, one called Engerix-B and the other one Recombivax HB. The vaccines are given as a series of three 3 ; injections to achieve maximal protection. Make sure that you receive the 3 shots: a first dose, the second dose after one month, and the third dose six months after first dose. The vaccine is generally well tolerated. Health care professionals that get infected through needle stick injury have access to a preventative vaccine that involves hepatitis B immune globulin HBIG ; , hepatitis B vaccine, or a combination of both. Who should be vaccinated? People with HIV, hepatitis C or other chronic liver disease, individuals who have multiple sexual partners, newborns & children up to age 19, health care professionals exposed to blood work, Injection drug users and people living in the same household with a chronically infected individual. Prevention Individuals should practice safe sex, use condom, not share personal care items that might have blood on them razors, toothbrushes ; , consider the risks if you are thinking about getting a tattoo or body piercing, don't share needles, syringes, water, or "works" with other people. Liver health If it is not already done, get vaccinated against hepatitis A and hepatitis B Dink lots of water at least 6 to 8 glasses a day ; If you have chronic liver disease, drinking alcohol can worsen your liver condition. Alcohol can greatly increase the risk of alcoholic and hepatitis C cirrhosis Be aware of drugs, herbal remedies, over-the- counter medications, recreational or street drugs that can be harsh for your liver. If you have advance liver disease, make sure you see your doctor regularly and you may have to consider to make a few changes into your dietary intake; protein, fats, salt, iron, etc. You may want to meet with a dietitian to review your nutrition needs. Written by Bertrand Toulouse for NATAP.
By Aaron Smith, CNNMoney staff writer January 29 2007: 12: EST NEW YORK CNNMoney ; -- The beleaguered Bristol-Myers Squibb could finally resolve its leadership troubles and bury its troubled past, if the U.S. company merges with the French giant Sanofi-Aventis to become the biggest drug company in the world and rimonabant.
Jason O. Robertson, Case Western Reserve University School of Medicine Jonathan D. Smith, Ph.D.
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If you have asthma, you may know about UPMC for You's asthma program. UPMC for You started the asthma program in 1999. It offers health education to everyone with an asthma diagnosis at no cost. There are several levels of the education program. The levels are based on the support you feel that you need. Everyone in the program gets: access to Internet health tools mailed asthma information reminders about health care tests Based on your needs, you may get weekly or monthly telephone calls from case managers. You may also get additional educational material, action plans, health surveys, and coordination of home health care. All of this effort by UPMC for You is aimed at making sure members get the care they need--such as regular physician or allergist exams. We want to be sure our members are as healthy as possible. A regular program of physician visits is important. Consistent use of required medication and inhalers may also keep you out of the hospital. When hospital visits are necessary, UPMC for You works closely with participating hospitals and doctors to make sure our members get the treatment they need. If you would like to talk to someone about our asthma health management program, call UPMC for You toll-free at 1-866-778-6073 TTY: 1-800-361-2629 ; , or mention the program to your doctor. Our staff members are available to assist you Monday through Friday from 8 a.m. to 4: 30 p.m.
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We thank the people who participated in this study, Heather Boon and Jenny Donovan the independent reviewers ; for their helpful comments, and Sally Macintyre for comments on an earlier draft. Contributors: All authors participated in the design of the study. AT conducted all the fieldwork and coding of the data. All authors contributed to data analysis and interpretation, although AT took the lead in the data analysis. All drafts of the paper were written by KH. All authors commented critically on each draft. KH and SW are guarantors for the paper Funding: This qualitative study was funded as a PhD studentship granted to AT by the Medical Research Council of Great Britain. The twenty-07 study, from which respondents for this qualitative study were drawn, is also funded by the MRC, and KH is an employee of the MRC. SW is employed by NHS Education for Scotland. Competing interests: None declared Ethical approval: Approval was obtained from the Glasgow University ethics committee for non clinical research involving human subjects.
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Separate study, it was demonstrated that the majority of patients with localization related partial epilepsy 57% ; become seizure free on medication. Patients with mesial temporal sclerosis were less likely to respond medically than those with other pathologies arteriovenous malformations, tumors, infarction, atrophy, and cortical dysplasia ; .16 Therefore Kwon and Brodie demonstrated that although many patients with lesional focal epilepsy become seizure free, patients who failed to respond to one or two antiepileptic medications will be difficult to control medically. These clinical results indicate that epilepsy surgery should be considered relatively early in the course of treatment in patients with mesial temporal lobe epilepsy because surgical treatment is more likely to achieve a seizure free outcome, without medication side effects. However, even in this selected population, surgery is not without risks, including decline in memory function. While anterior temporal lobectomy appears to be a cure for intractable epilepsy due to hippocampal sclerosis, this etiology accounts for a minority of patients with a medically intractable epilepsy. Approximately one half of patients with focal epilepsy due to MRI visualized cortical dysplasia will become free of disabling seizures following surgical resection.17 Patients with complete resection of the MRI apparent lesion are twice as likely to become seizure free 58% vs. 27% ; than those with incomplete resection. Results from surgical management of non-lesional focal epilepsy have been less promising. Additionally, patients with generalized epilepsy syndromes, multifocal epilepsy, and those patients with seizures originating from functional areas of cortex are not candidates for this treatment. Therefore, the search for an alternative in curative approaches such as localized drug delivery systems continue. For microstimulation or focal drug delivery systems to be effective methods, early detection of seizures is needed. Multiple paradigms for seizure detection are being developed. Jerger and colleagues compared seven different methods in their ability to detect intracranially recorded seizures.18 All of the methods were successful in anticipating seizures one to two minutes before a seizure was identified by a neurologist. This 1-2 minute time period is probably sufficient for local treatment strategies to be effective when they are developed and premphase.
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Relationship between use of thyroid medications and procedures and breast cancer riska Case n n 4502 ; % 84.2 15.8 Control n n 3867 737 4604 ; % 84.0 16.0 1.0 ORb 95% CI.
Fig. 1. The compartmental model used in the pharmacokinetic analysis of the intravenously delivered encapsulated glucocorticoid. All relevant fluxes are indicated more details in text.
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